Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling
S Shibata, M Nagase, T Fujita - Journal of the American Society of …, 2006 - journals.lww.com
Statins have been reported to confer renoprotection in several experimental models of renal
disease through pleiotropic actions. The roles of statins in glomerular podocytes have not
been explored. The objective of this study was to evaluate the effects of fluvastatin on
podocyte and tubulointerstitial injury in puromycin aminonucleoside (PAN)-induced
nephrosis. PAN induced massive proteinuria and serum creatinine elevation on day 7,
which were significantly suppressed by fluvastatin. Immunofluorescence studies of podocyte …
disease through pleiotropic actions. The roles of statins in glomerular podocytes have not
been explored. The objective of this study was to evaluate the effects of fluvastatin on
podocyte and tubulointerstitial injury in puromycin aminonucleoside (PAN)-induced
nephrosis. PAN induced massive proteinuria and serum creatinine elevation on day 7,
which were significantly suppressed by fluvastatin. Immunofluorescence studies of podocyte …