Klotho gene in human salt-sensitive hypertension

L Citterio, SD Carpini, S Lupoli, E Brioni… - Clinical Journal of the …, 2020 - journals.lww.com
Results Of the patients with hypertension, 35% were classified as salt sensitive. The most
relevant polymorphism associated with pressure natriuresis was the common missense
single nucleotide polymorphism rs9536314, and the GG and GT genotypes were more
represented among patients who were salt sensitive (P= 0.001). Those carrying the G allele
showed a less steep pressure-natriuresis relationship, meaning that a significant increase in
mean BP was needed to excrete the same quantity of salt compared with patients who were …