Mutation of the mouse klotho gene leads to a syndrome resembling ageing

M Kuro-o, Y Matsumura, H Aizawa, H Kawaguchi… - nature, 1997 - nature.com
M Kuro-o, Y Matsumura, H Aizawa, H Kawaguchi, T Suga, T Utsugi, Y Ohyama…
nature, 1997nature.com
A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome
that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin
atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares
sequence similarity with the β-glucosidase enzymes. The klotho gene product may function
as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related …
Abstract
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
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