Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway
disease. Thus it is important to define epigenetic alterations in asthmatic populations.
Objective We hypothesize that epigenetic alterations in circulating PBMCs are associated
with allergic asthma. Methods We compared DNA methylation patterns and gene expression
in inner-city children with persistent atopic asthma versus healthy control subjects by using …