Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A
Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-
1β and IL-17A factors, which also activate mast cells via PAR-2. 9 These factors may
further induce a large amount of histamine release from mast cells and robust edema
formation recognized as wheals. Combined application of antagonists against histamine H1
receptor, TLRs, and PAR, inhibitors of activated coagulation factors, such as FXa, and/or
agonist against adenosine receptors could be effective therapeutic targets for patients with …
1β and IL-17A factors, which also activate mast cells via PAR-2. 9 These factors may
further induce a large amount of histamine release from mast cells and robust edema
formation recognized as wheals. Combined application of antagonists against histamine H1
receptor, TLRs, and PAR, inhibitors of activated coagulation factors, such as FXa, and/or
agonist against adenosine receptors could be effective therapeutic targets for patients with …