[HTML][HTML] Improved long-term graft survival after HO-1 induction in brain-dead donors
K Kotsch, M Francuski, A Pascher, R Klemz… - American journal of …, 2006 - Elsevier
Brain death (BD) of the donor, a risk factor uniquely relevant for organs derived from cadaver
donors, influences organ quality by induction of various inflammatory events. Consequently
ischemia/reperfusion injury is deteriorated and acute and chronic rejections accelerated.
Donor treatment might be an approach to improve the quality of the graft. The induction of
heme oxygenase 1 (HO-1) has been shown to exert beneficial effects in living-donor
transplantation models. Therefore, we examined the impact of donor treatment with the …
donors, influences organ quality by induction of various inflammatory events. Consequently
ischemia/reperfusion injury is deteriorated and acute and chronic rejections accelerated.
Donor treatment might be an approach to improve the quality of the graft. The induction of
heme oxygenase 1 (HO-1) has been shown to exert beneficial effects in living-donor
transplantation models. Therefore, we examined the impact of donor treatment with the …