[HTML][HTML] The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes
S Cording, B Wahl, D Kulkarni, H Chopra, J Pezoldt… - Mucosal …, 2014 - Elsevier
De novo induction of Foxp3+ regulatory T cells (Tregs) is particularly efficient in gut-draining
mesenteric and celiac lymph nodes (mLN and celLN). Here we used LN transplantations to
dissect the contribution of stromal cells and environmental factors to the high Treg-inducing
capacity of these LN. After transplantation into the popliteal fossa, mLN and celLN retained
their high Treg-inducing capacity, whereas transplantation of skin-draining LN into the gut
mesenteries did not enable efficient Treg induction. However, de novo Treg induction was …
mesenteric and celiac lymph nodes (mLN and celLN). Here we used LN transplantations to
dissect the contribution of stromal cells and environmental factors to the high Treg-inducing
capacity of these LN. After transplantation into the popliteal fossa, mLN and celLN retained
their high Treg-inducing capacity, whereas transplantation of skin-draining LN into the gut
mesenteries did not enable efficient Treg induction. However, de novo Treg induction was …