Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonary fibrosis
R Herro, RDS Antunes, AR Aguilera, K Tamada… - Journal of Allergy and …, 2015 - Elsevier
Background Pulmonary fibrosis is characterized by excessive accumulation of collagen and
α-smooth muscle actin in the lung. The key molecules that promote these phenotypes are of
clinical interest. Objectives Thymic stromal lymphopoietin (TSLP) has been found at high
levels in patients with asthma and idiopathic pulmonary fibrosis, and TSLP has been
proposed as a primary driver of lung fibrotic disease. We asked whether tumor necrosis
factor superfamily protein 14 (TNFSF14)(aka LIGHT) controls TSLP production to initiate …
α-smooth muscle actin in the lung. The key molecules that promote these phenotypes are of
clinical interest. Objectives Thymic stromal lymphopoietin (TSLP) has been found at high
levels in patients with asthma and idiopathic pulmonary fibrosis, and TSLP has been
proposed as a primary driver of lung fibrotic disease. We asked whether tumor necrosis
factor superfamily protein 14 (TNFSF14)(aka LIGHT) controls TSLP production to initiate …