Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) neurotoxicity reproduces many of the
features of Parkinson's disease (PD). α-Synuclein has been identified as a prominent
component of the Lewy body (LB), the pathological hallmark of PD. MPTP-treated primates
have been reported to develop intraneuronal inclusions but not true Lewy bodies. We
administered MPTP to baboons and used a monoclonal α-synuclein antibody to define the
relationship between neuronal degeneration and α-synuclein immunoreactivity in the …