Urine has become one of the most attractive biofluids in clinical proteomics as it can be
obtained non-invasively in large quantities and is stable compared with other biofluids. The
urinary proteome has been studied by almost any proteomics technology, but mass
spectrometry-based urinary protein and peptide profiling has emerged as most suitable for
clinical application. After a period of descriptive urinary proteomics the field is moving out of
the discovery phase into an era of validation of urinary biomarkers in larger prospective …