[HTML][HTML] Activation-modulated association of 14–3–3 proteins with Cbl in T cells
YC Liu, C Elly, H Yoshida, N Bonnefoy-Berard… - Journal of Biological …, 1996 - ASBMB
14-3-3 proteins have recently been implicated in the regulation of intracellular signaling
pathways via their interaction with several oncogene and protooncogene products. We
found recently that 14–3–3 associates with several tyrosine-phosphorylated proteins and
phosphatidylinositol 3-kinase (PI3-K) in T cells. We report here the identification of the 120-
kDa 14–3–3τ-binding phosphoprotein present in activated T cell lysates as Cbl, a
protooncogene product of unknown function which was found recently to be a major protein …
pathways via their interaction with several oncogene and protooncogene products. We
found recently that 14–3–3 associates with several tyrosine-phosphorylated proteins and
phosphatidylinositol 3-kinase (PI3-K) in T cells. We report here the identification of the 120-
kDa 14–3–3τ-binding phosphoprotein present in activated T cell lysates as Cbl, a
protooncogene product of unknown function which was found recently to be a major protein …