Beta 1-integrin-mediated cell signaling in T lymphocytes
S Iwata, Y Ohashi, K Kamiguchi, C Morimoto - Journal of dermatological …, 2000 - Elsevier
β1-integrins play crucial roles in a variety of cell processes such as adhesion, migration,
proliferation, and differentiation of lymphocytes. For understanding the molecular
mechanisms of these various biological effects, it may be particularly important to analyze
cell signaling through the β1-integrins. Our previous study had shown that PLC-γ, pp125FAK
(focal adhesion kinase), pp105, paxillin, p59fyn, p56lck and ERK1/2 are phosphorylated in
their tyrosine residues upon engagement of β1-integrins. We identified pp105 as Cas (Crk …
proliferation, and differentiation of lymphocytes. For understanding the molecular
mechanisms of these various biological effects, it may be particularly important to analyze
cell signaling through the β1-integrins. Our previous study had shown that PLC-γ, pp125FAK
(focal adhesion kinase), pp105, paxillin, p59fyn, p56lck and ERK1/2 are phosphorylated in
their tyrosine residues upon engagement of β1-integrins. We identified pp105 as Cas (Crk …