Heme and FLVCR-related transporter families SLC48 and SLC49
AA Khan, JG Quigley - Molecular aspects of medicine, 2013 - Elsevier
Heme is critical for a variety of cellular processes, but excess intracellular heme may result
in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor
(FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme
exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1
function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations
of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative …
in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor
(FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme
exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1
function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations
of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative …