Distinct role of macrophages in different tumor microenvironments

CE Lewis, JW Pollard - Cancer research, 2006 - AACR
CE Lewis, JW Pollard
Cancer research, 2006AACR
Macrophages are prominent in the stromal compartment of virtually all types of malignancy.
These highly versatile cells respond to the presence of stimuli in different parts of tumors
with the release of a distinct repertoire of growth factors, cytokines, chemokines, and
enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct
microenvironments where tumor-associated macrophages (TAM) act include areas of
invasion where TAMs promote cancer cell motility, stromal and perivascular areas where …
Abstract
Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility, stromal and perivascular areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stimulate angiogenesis. This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes. (Cancer Res 2006; 66(2): 605-12)
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