[HTML][HTML] The human HSP70 family of chaperones: where do we stand?

J Radons - Cell Stress and Chaperones, 2016 - Elsevier
The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms.
Members of the HSP70 family control all aspects of cellular proteostasis such as nascent
protein chain folding, protein import into organelles, recovering of proteins from aggregation,
and assembly of multi-protein complexes. These chaperones augment organismal survival
and longevity in the face of proteotoxic stress by enhancing cell viability and facilitating …