Activated platelets may adhere to leukocytes and form circulating mixed aggregates. The
latter are considered a reliable marker of a prothrombotic state and are associated with
several cardiovascular conditions. The molecular mechanisms responsible of this cellular
interaction include a central role of platelet P-selectin and of P-selectin glycoprotein ligand-1
(PSGL-1), its counter receptor on leukocytes in a signaling cascade, resulting in the
activation of the beta-2 integrin Mac-1 and in the firm adhesion between the two cell types …