Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia–reperfusion injury
M Zhang, MC Carroll - Expert opinion on biological therapy, 2007 - Taylor & Francis
M Zhang, MC Carroll
Expert opinion on biological therapy, 2007•Taylor & FrancisRecent studies showed that innate autoimmunity is an early mechanism for ischemia–
reperfusion (I/R) injury. Results from different animal models showed that reperfusion of
ischemic tissues elicits an acute inflammatory response involving a complement system,
which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were
identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting
natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.
reperfusion (I/R) injury. Results from different animal models showed that reperfusion of
ischemic tissues elicits an acute inflammatory response involving a complement system,
which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were
identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting
natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.
Recent studies showed that innate autoimmunity is an early mechanism for ischemia–reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.
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