Cancer immunotherapy and the value of cure
JC Del Paggio - Nature Reviews Clinical Oncology, 2018 - nature.com
JC Del Paggio
Nature Reviews Clinical Oncology, 2018•nature.comPatients value anticancer therapies that provide durable clinical responses; immune-
checkpoint inhibitors can provide such benefit for patients with some advanced-stage
malignancies, albeit only for a minority of those treated. Modern oncology value frameworks
have set efficacy thresholds in an attempt to assess the clinical benefit of anticancer
therapeutics. But, is the benefit of durable cancer control reflected in these thresholds?
checkpoint inhibitors can provide such benefit for patients with some advanced-stage
malignancies, albeit only for a minority of those treated. Modern oncology value frameworks
have set efficacy thresholds in an attempt to assess the clinical benefit of anticancer
therapeutics. But, is the benefit of durable cancer control reflected in these thresholds?
Patients value anticancer therapies that provide durable clinical responses; immune-checkpoint inhibitors can provide such benefit for patients with some advanced-stage malignancies, albeit only for a minority of those treated. Modern oncology value frameworks have set efficacy thresholds in an attempt to assess the clinical benefit of anticancer therapeutics. But, is the benefit of durable cancer control reflected in these thresholds?
nature.com