[HTML][HTML] Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability
M Umeda, N Murata-Kamiya, Y Saito, Y Ohba… - Journal of biological …, 2009 - ASBMB
Infection with cagA-positive Helicobacter pylori is the strongest risk factor for the
development of gastric carcinoma. The cagA gene product CagA, which is delivered into
gastric epithelial cells, specifically binds to and aberrantly activates SHP-2 oncoprotein.
CagA also interacts with and inhibits partitioning-defective 1 (PAR1)/MARK kinase, which
phosphorylates microtubule-associated proteins to destabilize microtubules and thereby
causes epithelial polarity defects. In light of the notion that microtubules are not only …
development of gastric carcinoma. The cagA gene product CagA, which is delivered into
gastric epithelial cells, specifically binds to and aberrantly activates SHP-2 oncoprotein.
CagA also interacts with and inhibits partitioning-defective 1 (PAR1)/MARK kinase, which
phosphorylates microtubule-associated proteins to destabilize microtubules and thereby
causes epithelial polarity defects. In light of the notion that microtubules are not only …