[HTML][HTML] Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules
JI Sesma, CR Esther, SM Kreda, L Jones… - Journal of biological …, 2009 - ASBMB
Extracellular UDP-sugars promote cellular responses by interacting with widely distributed
P2Y 14 receptors, but the mechanisms by which these molecules are released from cells are
poorly understood. Given the active role of UDP-sugars in glycosylation reactions within the
secretory pathway, we hypothesized that UDP-sugar release includes an exocytotic
component. This hypothesis was tested by assessing the contribution of endoplasmic
reticulum (ER)/Golgi-resident UDP-GlcNAc transporters to the cellular release of their …
P2Y 14 receptors, but the mechanisms by which these molecules are released from cells are
poorly understood. Given the active role of UDP-sugars in glycosylation reactions within the
secretory pathway, we hypothesized that UDP-sugar release includes an exocytotic
component. This hypothesis was tested by assessing the contribution of endoplasmic
reticulum (ER)/Golgi-resident UDP-GlcNAc transporters to the cellular release of their …