In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular
patterns (DAMPs). DAMPs represent a heterogeneous group of molecules that draw their
origin either from inside the various compartments of the cell or from the extracellular space.
Following interaction with pattern recognition receptors in cross-talk with various non-
immune receptors, DAMPs determine the downstream signaling outcome of septic and …