Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis
Y Yao, ZC Wang, N Wang, PC Zhou, CL Chen… - Journal of Allergy and …, 2019 - Elsevier
Background The function of follicular regulatory T (T FR) cells, especially in regulating IgE
production in patients with allergic diseases, is poorly understood. Objective We sought to
investigate the phenotype, function, and clinical relevance of T FR cells in patients with
allergic rhinitis (AR). Methods The phenotype and frequency of tonsillar and circulating T FR
cells were characterized by using flow cytometry. T FR cell function was examined in an
assay by coculturing with follicular helper T cells and B cells. The associations between T …
production in patients with allergic diseases, is poorly understood. Objective We sought to
investigate the phenotype, function, and clinical relevance of T FR cells in patients with
allergic rhinitis (AR). Methods The phenotype and frequency of tonsillar and circulating T FR
cells were characterized by using flow cytometry. T FR cell function was examined in an
assay by coculturing with follicular helper T cells and B cells. The associations between T …