Background: Peanut allergy affects 0.6% of the US population. At the present time, allergen
avoidance is the only therapeutic option. Animal models of food-induced anaphylaxis would
facilitate attempts to design novel immunotherapeutic strategies for the treatment of peanut
allergy. Objective: The purpose of this study was to develop a murine model of IgE-mediated
peanut hypersensitivity that closely mimics human peanut allergy. Methods: C3H/HeJ mice
sensitized orally with freshly ground whole peanut and cholera toxin as adjuvant were …