Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection

D Botta, MJ Fuller, TT Marquez-Lago, H Bachus… - Nature …, 2017 - nature.com
D Botta, MJ Fuller, TT Marquez-Lago, H Bachus, JE Bradley, AS Weinmann, AJ Zajac…
Nature immunology, 2017nature.com
Abstract Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits
T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular
regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an
influenza infection model, we found that high IL-2 concentrations at the peak of the infection
prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the
immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and …
Abstract
Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses.
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