[HTML][HTML] Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections
CML Wager, FL Wormley Jr - Mucosal immunology, 2014 - Elsevier
Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in
host defense against various microbial pathogens, including fungi, while alternatively
activated macrophages are instrumental in immune-regulation and wound healing.
Macrophages in the lungs are often the first responders to pulmonary fungal pathogens, and
the macrophage polarization state has the potential to be a deciding factor in disease …
different phenotypes. Classically activated macrophages are known to have major roles in
host defense against various microbial pathogens, including fungi, while alternatively
activated macrophages are instrumental in immune-regulation and wound healing.
Macrophages in the lungs are often the first responders to pulmonary fungal pathogens, and
the macrophage polarization state has the potential to be a deciding factor in disease …