[HTML][HTML] PI3 kinase signals BCR-dependent mature B cell survival

L Srinivasan, Y Sasaki, DP Calado, B Zhang, JH Paik… - Cell, 2009 - cell.com
L Srinivasan, Y Sasaki, DP Calado, B Zhang, JH Paik, RA DePinho, JL Kutok, JF Kearney
Cell, 2009cell.com
Previous work has shown that mature B cells depend upon survival signals delivered to the
cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal,
we have developed a genetic approach in which ablation of the BCR is combined with the
activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using
this system, we provide evidence that the survival of BCR deficient mature B cells can be
rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with …
Summary
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.
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