[HTML][HTML] TSLP signaling network revealed by SILAC-based phosphoproteomics
Thymic stromal lymphopoietin (TSLP) is a cytokine that plays diverse roles in the regulation
of immune responses. TSLP requires a heterodimeric receptor complex consisting of IL-7
receptor α subunit and its unique TSLP receptor (gene symbol CRLF2) to transmit signals in
cells. Abnormal TSLP signaling (eg overexpression of TSLP or its unique receptor TSLPR)
contributes to the development of a number of diseases including asthma and leukemia.
However, a detailed understanding of the signaling pathways activated by TSLP remains …
of immune responses. TSLP requires a heterodimeric receptor complex consisting of IL-7
receptor α subunit and its unique TSLP receptor (gene symbol CRLF2) to transmit signals in
cells. Abnormal TSLP signaling (eg overexpression of TSLP or its unique receptor TSLPR)
contributes to the development of a number of diseases including asthma and leukemia.
However, a detailed understanding of the signaling pathways activated by TSLP remains …