Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”
A Aouacheria, KW Cunningham, JM Hardwick… - Science, 2018 - science.org
Science, 2018•science.org
Shlezinger et al.(Reports, 8 September 2017, p. 1037) report that the common fungus
Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-
like cell death triggered by lung neutrophils. However, the technologies they used do not
provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by
a fungal caspase inhibitor homologous to human survivin.
Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-
like cell death triggered by lung neutrophils. However, the technologies they used do not
provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by
a fungal caspase inhibitor homologous to human survivin.
Shlezinger et al. (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
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