Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility
R Stadhouders, BWS Li, MJW de Bruijn… - Journal of Allergy and …, 2018 - Elsevier
Background Group 2 innate lymphoid cells (ILC2s) are major producers of the cytokines
driving allergic asthma, and increased ILC2 numbers have been detected in blood and
sputum of asthmatic patients. Asthma susceptibility has a strong genetic component, but the
underlying mechanisms and whether asthma genetics affect ILC2 biology remain unclear.
Objective We sought to study the ILC2 transcriptome and epigenome during airway
inflammation (AI) to couple these to genes and genetic variants associated with asthma …
driving allergic asthma, and increased ILC2 numbers have been detected in blood and
sputum of asthmatic patients. Asthma susceptibility has a strong genetic component, but the
underlying mechanisms and whether asthma genetics affect ILC2 biology remain unclear.
Objective We sought to study the ILC2 transcriptome and epigenome during airway
inflammation (AI) to couple these to genes and genetic variants associated with asthma …