nNOS mediated mitochondrial injury in LPS stimulated oligodendrocytes
SY Yao, C Natarajan, S Sriram - Mitochondrion, 2012 - Elsevier
Products of inflammation and the activation of nitric oxide synthase have been proposed as
a mechanism of oligodendrocyte injury in CNS inflammation. There are currently three well
described and known isoforms of NOS. Of these, neuronal NOS (nNOS) was initially
discovered in neurons, endothelial NOS (eNOS) in vascular endothelium, while the
inducible form of NOS (iNOS) is known to be activated in oligodendrocytes, astrocytes and
microglia. We examined the activation of nNOS and the down stream effects of NO …
a mechanism of oligodendrocyte injury in CNS inflammation. There are currently three well
described and known isoforms of NOS. Of these, neuronal NOS (nNOS) was initially
discovered in neurons, endothelial NOS (eNOS) in vascular endothelium, while the
inducible form of NOS (iNOS) is known to be activated in oligodendrocytes, astrocytes and
microglia. We examined the activation of nNOS and the down stream effects of NO …