[HTML][HTML] AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts
Y Morizane, A Thanos, K Takeuchi, Y Murakami… - Journal of Biological …, 2011 - ASBMB
Matrix metalloproteinase-9 (MMP-9) plays a critical role in tissue remodeling under both
physiological and pathological conditions. Although MMP-9 expression is low in most cells
and is tightly controlled, the mechanism of its regulation is poorly understood. We utilized
mouse embryonic fibroblasts (MEFs) that were nullizygous for the catalytic α subunit of AMP-
activated protein kinase (AMPK), which is a key regulator of energy homeostasis, to identify
AMPK as a suppressor of MMP-9 expression. Total AMPKα deletion significantly elevated …
physiological and pathological conditions. Although MMP-9 expression is low in most cells
and is tightly controlled, the mechanism of its regulation is poorly understood. We utilized
mouse embryonic fibroblasts (MEFs) that were nullizygous for the catalytic α subunit of AMP-
activated protein kinase (AMPK), which is a key regulator of energy homeostasis, to identify
AMPK as a suppressor of MMP-9 expression. Total AMPKα deletion significantly elevated …