[HTML][HTML] A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers

AB Riemer, DB Keskin, G Zhang, M Handley… - Journal of Biological …, 2010 - ASBMB
Human Papillomavirus 16 (HPV-16) has been identified as the causative agent of 50% of
cervical cancers and many other HPV-associated tumors. The transforming potential/tumor
maintenance capacity of this high risk HPV is mediated by two viral oncoproteins, E6 and
E7, making them attractive targets for therapeutic vaccines. Of 21 E6 and E7 peptides
computed to bind HLA-A* 0201, 10 were confirmed through TAP-deficient T2 cell HLA
stabilization assay. Those scoring positive were investigated to ascertain which were …