[HTML][HTML] Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig

J Chen, H Yin, J Xu, Q Wang, KL Edelblum… - American Journal of …, 2013 - Elsevier
Alloantibodies mediate acute antibody-mediated rejection as well as chronic allograft
rejection in clinical transplantation. To better understand the cellular dynamics driving
antibody production, we focused on the activation and differentiation of alloreactive B cells in
the draining lymph nodes and spleen following sensitization to allogeneic cells or hearts.
We used a modified staining approach with a single MHC Class I tetramer (K d) bound to
two different fluorochromes to discriminate between the Class I-binding and fluorochrome …