Interferon gamma (IFN-γ), being the hallmark of the T-cell TH1 response, has been
extensively studied with respect to its expression and regulation of immune function. This
gene has been extensively characterized in many mammalian species, making it one of the
most widely cloned immunoregulatory genes. Recently, the gene has been identified in
avian and piscine species and we have identified the gene in the frog genome. Based on
these identified DNA sequences, we have constructed an evolutionary history of IFN-γ that …