Renal dysfunction, rather than nonrenal vascular dysfunction, mediates salt-induced hypertension

JE Hall - Circulation, 2016 - Am Heart Assoc
JE Hall
Circulation, 2016Am Heart Assoc
Hall Kidney Dysfunction in Salt-Induced Hypertension 895 induced experimentally or by
genetic mutations, has not been shown to increase salt sensitivity of BP. In this review, I
discuss evidence that kidney dysfunction is required for chronic increases in BP in subjects
who are salt sensitive and that vasoconstriction of nonrenal blood vessels, although present
in salt-induced hypertension, is insufficient to chronically increase BP in the absence of
kidney dysfunction. Evidence that vasoconstriction during salt loading may be secondary to …
Hall Kidney Dysfunction in Salt-Induced Hypertension 895 induced experimentally or by genetic mutations, has not been shown to increase salt sensitivity of BP. In this review, I discuss evidence that kidney dysfunction is required for chronic increases in BP in subjects who are salt sensitive and that vasoconstriction of nonrenal blood vessels, although present in salt-induced hypertension, is insufficient to chronically increase BP in the absence of kidney dysfunction. Evidence that vasoconstriction during salt loading may be secondary to increased BP, serving to protect tissues from pressure or flow overload, is also reviewed. 12, 15
Am Heart Assoc