Abstract αKlotho is a multifunctional protein highly expressed in the kidney. Soluble αKlotho
is released through cleavage of the extracellular domain from membrane αKlotho by
secretases to function as an endocrine/paracrine substance. The role of the kidney in
circulating αKlotho production and handling is incompletely understood, however. Here, we
found higher αKlotho concentration in suprarenal compared with infrarenal inferior vena
cava in both rats and humans. In rats, serum αKlotho concentration dropped precipitously …