The Wnts include a large family of secreted proteins that serve as important signals during
embryonic development and adult homeostasis. In the most well understood Wnt signaling
pathway, Wnt binding to Frizzled and low density lipoprotein receptor-related protein
induces β-catenin protein stabilization and entry into the nucleus, resulting in changes in
target gene transcription. Emerging evidence suggests that Wnt5a can inhibit Wnt/β-catenin
signaling through interaction with the receptor Ror2. The Ror2 protein belongs to the …