Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection
CR Sturge, F Yarovinsky - Infection and immunity, 2014 - Am Soc Microbiol
CR Sturge, F Yarovinsky
Infection and immunity, 2014•Am Soc MicrobiolToxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in
immunocompromised patients. Investigations into the immune response to the parasite
found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated
host resistance. However, recent studies have revealed a critical role for the innate immune
system in mediating host defense independently of the T cell responses to the parasite. This
body of knowledge is put into perspective by the unifying theme that immunity to the …
immunocompromised patients. Investigations into the immune response to the parasite
found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated
host resistance. However, recent studies have revealed a critical role for the innate immune
system in mediating host defense independently of the T cell responses to the parasite. This
body of knowledge is put into perspective by the unifying theme that immunity to the …
Abstract
Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ-producing cells and the signals that regulate IFN-γ production during T. gondii infection.
American Society for Microbiology