Pro-senescence therapy for cancer treatment
C Nardella, JG Clohessy, A Alimonti… - Nature Reviews …, 2011 - nature.com
Nature Reviews Cancer, 2011•nature.com
Abundant evidence points to a crucial physiological role for cellular senescence in
combating tumorigenesis. Thus, the engagement of senescence may represent a key
component for therapeutic intervention in the eradication of cancer. In this Opinion article,
we focus on concepts that are relevant to a pro-senescence approach to therapy and we
propose potential therapeutic strategies that aim to enhance the pro-senescence response
in tumours.
combating tumorigenesis. Thus, the engagement of senescence may represent a key
component for therapeutic intervention in the eradication of cancer. In this Opinion article,
we focus on concepts that are relevant to a pro-senescence approach to therapy and we
propose potential therapeutic strategies that aim to enhance the pro-senescence response
in tumours.
Abstract
Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.
nature.com