[PDF][PDF] HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

JD Gordan, CB Thompson, MC Simon - Cancer cell, 2007 - cell.com
JD Gordan, CB Thompson, MC Simon
Cancer cell, 2007cell.com
O 2 deprivation (hypoxia) and cellular proliferation engage opposite cellular pathways, yet
often coexist during tumor growth. The ability of cells to grow during hypoxia results in part
from crosstalk between hypoxia-inducible factors (HIFs) and the proto-oncogene c-Myc.
Acting alone, HIF and c-Myc partially regulate complex adaptations undertaken by tumor
cells growing in low O 2. However, acting in concert these transcription factors reprogram
metabolism, protein synthesis, and cell cycle progression, to" fine tune" adaptive responses …
O2 deprivation (hypoxia) and cellular proliferation engage opposite cellular pathways, yet often coexist during tumor growth. The ability of cells to grow during hypoxia results in part from crosstalk between hypoxia-inducible factors (HIFs) and the proto-oncogene c-Myc. Acting alone, HIF and c-Myc partially regulate complex adaptations undertaken by tumor cells growing in low O2. However, acting in concert these transcription factors reprogram metabolism, protein synthesis, and cell cycle progression, to "fine tune" adaptive responses to hypoxic environments.
cell.com