[HTML][HTML] Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase
JW Zmijewski, S Banerjee, H Bae, A Friggeri… - Journal of Biological …, 2010 - ASBMB
Although metabolic conditions associated with an increased AMP/ATP ratio are primary
factors in the activation of 5′-adenosine monophosphate-activated protein kinase (AMPK),
a number of recent studies have shown that increased intracellular levels of reactive oxygen
species can stimulate AMPK activity, even without a decrease in cellular levels of ATP. We
found that exposure of recombinant AMPKαβγ complex or HEK 293 cells to H 2 O 2 was
associated with increased kinase activity and also resulted in oxidative modification of …
factors in the activation of 5′-adenosine monophosphate-activated protein kinase (AMPK),
a number of recent studies have shown that increased intracellular levels of reactive oxygen
species can stimulate AMPK activity, even without a decrease in cellular levels of ATP. We
found that exposure of recombinant AMPKαβγ complex or HEK 293 cells to H 2 O 2 was
associated with increased kinase activity and also resulted in oxidative modification of …