[HTML][HTML] Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation
A Roy, G Ganesh, H Sippola, S Bolin, O Sawesi… - Journal of Biological …, 2014 - ASBMB
During infection and tissue damage, virulence factors and alarmins are pro-inflammatory
and induce activation of various immune cells including macrophages and mast cells (MCs).
Activated MCs instantly release preformed inflammatory mediators, including several
proteases. The chymase mouse mast cell protease (MCPT)-4 is thought to be pro-
inflammatory, whereas human chymase also degrades pro-inflammatory cytokines,
suggesting that chymase instead limits inflammation. Here we explored the contribution of …
and induce activation of various immune cells including macrophages and mast cells (MCs).
Activated MCs instantly release preformed inflammatory mediators, including several
proteases. The chymase mouse mast cell protease (MCPT)-4 is thought to be pro-
inflammatory, whereas human chymase also degrades pro-inflammatory cytokines,
suggesting that chymase instead limits inflammation. Here we explored the contribution of …