[HTML][HTML] Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate
M Dell'Aringa, RL Reinhardt - Mucosal immunology, 2018 - Elsevier
Type-2 immunity is regulated by two distinct CD4+ T-cell subsets. T follicular helper (Tfh)
cells are required for humoral hallmarks of type-2 inflammation. T-helper type-2 (Th2) cells
orchestrate type-2 inflammation in peripheral tissues, such as the lung and intestine. Given
the importance of Notch signaling in the establishment of other CD4+ T-helper cell subsets,
we investigated whether canonical Notch activation could differentially impact Tfh and Th2
cell fate during the induction of type-2 immunity. These studies show that Tfh cell, but not …
cells are required for humoral hallmarks of type-2 inflammation. T-helper type-2 (Th2) cells
orchestrate type-2 inflammation in peripheral tissues, such as the lung and intestine. Given
the importance of Notch signaling in the establishment of other CD4+ T-helper cell subsets,
we investigated whether canonical Notch activation could differentially impact Tfh and Th2
cell fate during the induction of type-2 immunity. These studies show that Tfh cell, but not …