The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma
A KleinJan, I Tindemans, JE Montgomery… - Journal of Allergy and …, 2018 - Elsevier
Background The Notch signaling pathway has been implicated in the pathogenesis of
allergic airway inflammation. Targeting the active Notch transactivation complex by using the
cell-permeable, hydrocarbon-stapled synthetic peptide stapled α-helical peptide derived
from mastermind-like 1 (SAHM1) resulted in genome-wide suppression of Notch-activated
genes in leukemic cells and other models. However, the efficacy of SAHM1 in allergic
asthma models has remained unexplored. Objective We aimed to investigate the therapeutic …
allergic airway inflammation. Targeting the active Notch transactivation complex by using the
cell-permeable, hydrocarbon-stapled synthetic peptide stapled α-helical peptide derived
from mastermind-like 1 (SAHM1) resulted in genome-wide suppression of Notch-activated
genes in leukemic cells and other models. However, the efficacy of SAHM1 in allergic
asthma models has remained unexplored. Objective We aimed to investigate the therapeutic …