Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation
and cancer metastasis and develop in a dynamic process (called lymphangiogenesis)
involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen
in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as
indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of
development as Vegfc and is required for lymphangioblast budding and angiogenic …