[HTML][HTML] Parkinson's disease-associated protein Parkin: an unusual player in cancer
J Liu, C Zhang, W Hu, Z Feng - Cancer Communications, 2018 - Springer
J Liu, C Zhang, W Hu, Z Feng
Cancer Communications, 2018•SpringerThe mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body
of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin
E3 ligase, and plays important roles in a variety of cellular processes implicated in
tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and
metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin
E3 ligase, and plays important roles in a variety of cellular processes implicated in
tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and
metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
Abstract
The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
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