[HTML][HTML] Constitutive role of the Fanconi anemia D2 gene in the replication stress response
In response to DNA cross-linking damage, the Fanconi anemia (FA) core complex activates
the FA pathway by monoubiquitinating Fanconi anemia complementation group D2
(FANCD2) for the initiation of the nucleolytic processing of the DNA cross-links and
stabilization of stalled replication forks. Given that all the classic FA proteins coordinately
monoubiquitinate FANCD2, it is unclear why losses of individual classic FA genes yield
varying cellular sensitivities to cross-linking damage. To address this question, we …
the FA pathway by monoubiquitinating Fanconi anemia complementation group D2
(FANCD2) for the initiation of the nucleolytic processing of the DNA cross-links and
stabilization of stalled replication forks. Given that all the classic FA proteins coordinately
monoubiquitinate FANCD2, it is unclear why losses of individual classic FA genes yield
varying cellular sensitivities to cross-linking damage. To address this question, we …