Animal models of gestational hypertension are problematic. A novel mouse model was
described earlier. The dams in that study were transgenic for human angiotensinogen and
the sires for human renin; human renin was expressed in and produced by the placenta.
This model was adapted to the rat, which has greater utility in terms of chronic
instrumentation and physiologic measurements. Female rats transgenic for human
angiotensinogen were mated with rats transgenic for human renin. Telemetry BP increased …