Tyrosine kinases (TKs) are central regulators in cellular activities and perturbations of TK
signaling contribute to oncogenesis. However, less than half of the TKs have been
thoroughly studied and a global functional analysis of their proteomic portrait is lacking.
Here we conducted a combined approach of RNA interference (RNAi) and stable isotope
labeling with amino acids in cell culture (SILAC)-based quantitative proteomics to decode
the TK-regulated proteome and associated signaling dynamics. As a result, a broad …