Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus
C Richez, P Blanco, I Rifkin, JF Moreau… - Joint Bone Spine, 2011 - Elsevier
Systemic lupus erythematosus (SLE) is a multisystem disease characterized by an
autoimmune response to nuclear antigens. Although the pathophysiology of SLE remains
incompletely understood, many recent studies indicate a major role for innate immunity. The
toll-like receptors (TLRs), which play a key role in innate responses to infections, are also
involved in acute and chronic inflammatory processes induced by endogenous ligands.
Numerous in vitro studies have established that TLR7 and TLR9 are involved in immune …
autoimmune response to nuclear antigens. Although the pathophysiology of SLE remains
incompletely understood, many recent studies indicate a major role for innate immunity. The
toll-like receptors (TLRs), which play a key role in innate responses to infections, are also
involved in acute and chronic inflammatory processes induced by endogenous ligands.
Numerous in vitro studies have established that TLR7 and TLR9 are involved in immune …